ABSTRACT
To determine microbial spectrum of catheter associated urinary tract infection and their antimicrobial susceptibility pattern in patients under intensive care. This is a descriptive and cross-sectional study, which was carried out at the Department of Microbiology Armed Forces Institute of Pathology, Rawalpindi. This institute is providing laboratory cover to two tertiary care hospital and five institutes of excellence. A total of 122 isolates, obtained from urine of 100 catheterized patients, at Armed Forces Institute of Pathology, Rawalpindi for a period of six months were included in the study. Identification was carried out by biochemical and serological profile of the organism. The antimicrobial susceptibility tests of isolated organisms were performed by standard disk diffusion method as recommend by Clinical Laboratory Standards Institute. Majority [68%] of the organisms isolated were Gram negative organisms while 32% of the infections were due to Gram positive organisms/fungi. Moxifloxacin [86.40%] and imipenem [83.30%] were the most active antibiotics. Resistance was very high to ampicillin [88.50%] and trimethoprim /sulfamethoxazole [75.00%]. Majority of the catheter associated urinary tract infections are due to Gram negative but Gram positive organisms and fungi are also causing UTIs in about one third cases. Resistance to the conventional antimicrobials used for UTI was high